Formulation Scientist/Engineer with Expertise in Amorphous Solid Dispersion

Mon, September 16, 2024

Summary

We are seeking a skilled and motivated Formulation Scientist specializing in amorphous solid Spray Dried Dispersions (SDD) to join our dynamic R&D team. The ideal candidate will possess a strong background in formulation development, process optimization, and analytical characterization of spray dried products. This position serves as a subject matter expert in SDD technology, focusing on driving the design and development of novel formulations for pharmaceuticals.

In this role, you will collaborate with crystallization scientists to influence the selection of small molecule drug candidates, optimizing the application of SDD technology to enhance drug delivery and bio-performance. You will be responsible for the development of optimal SDD composition and characterization to ensure appropriate in vivo performance. Your expertise will be crucial in advancing our innovative approaches to formulation science and improving patient outcomes.

Company Overview

Solid State Pharma Inc. (SSPI) is a pharmaceutical research company with expertise in crystallization engineering and solid-state science. SPPI has experienced great success with the workflows that have been developed by combining fundamentals of crystallization and solid form science with years of experience and high throughput techniques. SSPI is conducting research on pharmaceutical crystallization engineering, polymorph screening, salt screening, co-crystal screening, chiral resolution, polymorph quantification, converting amorphous material to crystalline solid, pre-formulation, and chemical and crystallization process modeling. SSPI is working with many global pharmaceutical companies to develop active pharmaceutical ingredients with consistent bioavailability and scalable manufacturing process.

Key Responsibilities:

• Design, develop, and optimize fit for purpose SDD formulations to improve solubility and bioavailability of active pharmaceutical ingredients (APIs).
• Conduct stability studies to assess the physical and chemical stability of formulations.
• Optimize spray drying parameters including polymer type and composition, inlet temperature, feed rate, and nozzle design to achieve desired product characteristics.
• Troubleshoot and resolve issues related to the spray drying process.
• Utilize various characterization techniques (e.g., DSC, TGA, PXRD, FTIR, SEM) to evaluate the properties of spray dried dispersions and ensure product quality.
• Evaluate the physicochemical properties of potential small molecule drug candidates to design an SSD formulation strategy and developability risk assessment.
• Be a subject matter expert in formulation and process development for SDDs supporting multiple discovery teams across several research units.
• Work collaboratively with scientists in the organization to understand and address key challenges in the SDD space.

We Share in the Prosperity We Create.

We offer competitive compensation, but we are not held back by rigid compensation grids and rules. The harder and smarter we work, the better we all do financially.

We also offer a competitive benefits plan to ensure our employees have the safety net we all need to be able to protect ourselves and our families from the unexpected. See below for a comprehensive list of employee benefits:

• Culture that supports continuous employee growth and encourages collaboration
• A friendly, diverse, and nurturing environment
• Bonus programs
• Free coverage for premium healthcare benefits through Blue Cross
• RRSP contribution matching program with free access to financial advisor
• Continuing education support program for eligible team members
• Flexible working hours in an innovative and fast paced industry
• Conference/travel opportunities for Technical Staff
• Generous vacation accrual and sick time policies
• Up to 22 weeks of 90% salary top-up for maternity and up to 5 weeks top-up for paternity
• Extensive holiday list
• Company events and monthly lunches
• Free in-house snacks and coffee
• COSTCO membership and professional membership coverage
• Downtown location with views of the Halifax harbour

Closing Date

Open until filled.

Contact information

Please submit resume and cover letter to career@solidstatepharma.com.