The Creative Destruction Lab is a seed-stage program for massively scalable, science- and technology-based ventures. It employs a unique, objectives-focused coaching process to help founders commercialize advances in science and technology. The program pairs startups with exited entrepreneurs and star scientists in areas such artificial intelligence, quantum computing, healthcare, blockchain, energy, and cleantech. Founded at the Rotman School of Management at the University of Toronto, CDL now operates locations in six cities including Vancouver, Calgary, Toronto, Montreal, Halifax, and New York City.

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