Work In Tech

AbCellera is breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. We are a team of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.

We are looking for a (Senior) Manager, Upstream Site MSAT to be the subject matter expert for GMP scale purification of monoclonal and bispecific antibodies, playing a key role in process and facility design. In this role, based in beautiful Vancouver, you will work closely with manufacturing operations, process development, engineering, quality and other technical operations functions. You will drive technology transfer, process controls, recipe and batch record development, technical troubleshooting and successful batch production in our new GMP manufacturing facility.

How you might spend your days

• Providing technical leadership as the subject matter expert for the cell culture process for monoclonal and/or bispecific antibodies
• Acting as the key receiver during technology transfer of new processes from process development and pilot plant operations, enabling scale-up, risk management, recipe development, batch record development, and overall engineering run and drug substance success
• Working closely with the 200L scale pilot plant operations team to prepare process risk assessments, raw material risk assessments, control strategies, and technology transfer documentation
• Contributing to process and facility design to enable best practices by design
• Providing technical support to enable bioprocessing decisions in manufacturing, championing best for process principles together with quality and manufacturing
• Designing manufacturing systems that are technically sound, promoting effective and efficient operations, and compliance with cGMP requirements
• Identifying opportunities in GMP appropriate technologies with a vision of improving processing time, yield, cost of goods and operational complexity

We’d love to hear from you if

• You have 8+ years of industry experience in the development and manufacturing of monoclonal and/or bispecific antibodies and a bachelor's degree in biotechnology, biochemistry, chemical engineering, molecular biology or a similar discipline
• You have outstanding technical acumen in mammalian cell culture, growth media preparation, scale-up and upstream operations to support robust processes for the expression of recombinant monoclonal and bispecific antibodies, scale up to 2000L
• You have significant knowledge of upstream processing methods to support pre-clinical and clinical programs, and a strong understanding of GMP compliance
• You have experience in technology transfer and in scaling monoclonal antibody processes from pilot to GMP scale
• You are passionate about building dynamic new teams and capabilities that accomplish important goals
• You are a creative and innovative thinker, with the ability to identify potential issues before they arise
• You have a strong operational acumen with experience in risk management, and can prioritize science and engineering approaches to prevent process downtime

What we offer

AbCellera’s hiring range for this role is CAD $92,000 - $115,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution.

You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, opportunity for flexible work arrangements, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you’ll find we prioritize teams and social groups to build community and connections across AbCellera.

About AbCellera

AbCellera is a global company that discovers and develops antibody-based medicines that help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.

And it all starts with our team. We’ve built a place where people feel they are part of something bigger than themselves. A place that exists to push the limits of science and technology, and aims to bring better therapies to patients.

We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success.